Resistance to FasL and TRAIL-mediated apoptosis in Sézary syndrome T-cells associated with impaired death receptor and cFLIP expression Short title: Apoptosis defects in Sézary syndrome T-cells
نویسندگان
چکیده
Department of Dermatology, Zürich University Hospital, Zürich, Switzerland; Louis-Jeantet Skin Cancer Laboratory, Department of Pathology and Immunology, University Medical Center, Geneva, Switzerland; Department of Dermatology, University Hospital, Geneva, Switzerland; Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia; Topotarget Switzerland, Lausanne, Switzerland.
منابع مشابه
Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression.
Because of the low proliferative potential of tumor cells in patients with Sézary syndrome (SzS), their accumulation has been suggested to be due to defective regulation of apoptosis. We analyzed the sensitivity to soluble Fas-ligand (FasL) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), 2 members of the TNF superfamily in peripheral blood leukocytes (PBL) from patien...
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